Tuesday, August 10, 2010

BK Virus Lands a Crushing Blow!

Went into the clinic today to see how things fared after last week's infusions. When the dust settled, it became apparent that the creatinine level had jumped to 5.6, a whopping 54% increase over last week's number. Just for reference, normal ranges between 0.3 and 1.1. That sucks!

Now the question is what caused this week's jump. Three options. One, the BK Virus is really ramping up. That was last week's theory and was why we did the infusions last Friday. Two, based on the extreme reaction to the IVIG, it is possible that the IVIG did damage to the kidney. Three, the Cidofovir, itself a noted nephrotoxin, did damage. 

The early favorites are the first two options. The BKV was already on a roll as evidenced by last week's numbers. The reaction to the IVIG was so strong and off the charts and it can damage the kidney. The dosage of Cidofovir was very low and controlled and the results are usually stable and predicitable. But really it's anyone's guess.

So now the plan is for me hydrate like fool today and to go to the clinic tomorrow and hope for better results. Assuming the numbers stay the same or continue to worsen, I'm scheduled for another biopsy on Thursday. The small sample of kidney tissue will tell us the nature of the damage to the kidney and give us true cell count of the BKV in the kidney itself.

And then????

I don't wanna think about it.

2 comments:

  1. Oh Dave!! That is so discouraging! I can't thank you enough for taking time to post this stuff, though. love you. mm

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  2. Polycystic Kidney Disease is a kidney disorder in which numerous cysts are formed in the kidneys. In such disorder inflammation of the kidneys occur because of the fluid buildup in these cysts.

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